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2 edition of Hormone effects on secreted and membrane proteins of "Xenopus laevis" liver found in the catalog.

Hormone effects on secreted and membrane proteins of "Xenopus laevis" liver

Martin, Simon.

Hormone effects on secreted and membrane proteins of "Xenopus laevis" liver

by Martin, Simon.

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Published by typescript in [s.l.] .
Written in English


Edition Notes

Thesis (M.Phil.) - University of Warwick, 1986.

Statementby Simon Martin.
ID Numbers
Open LibraryOL13863408M

The processing and secretion of rat serum albumin by oocytes from Xenopus laevis R.C. Foreman and J.D. Judah* A variety of eukaryote secreted proteins undergo post-translational proteolysis before release from the cell [1,2]. the enzyme cathepsin B is the convertase in rat liver [21]. We studied the effect of three protease in-. Protein knowledgebase. UniParc. Sequence archive. Help. Help pages, FAQs, UniProtKB manual, documents, news archive and Biocuration projects. UniRef. Sequence clusters. Proteomes. Protein sets from fully sequenced genomes. Annotation systems. Systems used to automatically annotate proteins with high accuracy: UniRule (Expertly curated rules).

  Oestradiolβ induces livers of Xenopus laevis (South African clawed toad) to synthesize and secrete into the serum large quantities of the egg-yolk-protein precursor, vitellogenin. The peak of this response occurs 9–16 days after hormone treatment [Dolphin, Ansari, Lazier, Munday & Akhtar () by:   Furthermore, it has been shown that the progesterone effect can be reduced by antibodies against the progesterone membrane-binding protein (mPR) 24, which was isolated previously from liver by:

Thyroid hormone-binding protein, with a much higher binding affinity for triiodothyronine (T3) than for thyroxine (T4). Probably transports triiodothyronine from the bloodstream to the brain.   Abstract. Amphibian metamorphosis is driven by thyroid hormone (TH). We used prometamorphic tadpoles and a cell line of the African clawed frog (Xenopus laevis) to examine immediate effects of dioxin exposure on expression patterns suggest cross-talk between the thyroid hormone receptor (TR) and aryl hydrocarbon receptor (AHR) signaling by: 4.


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Hormone effects on secreted and membrane proteins of "Xenopus laevis" liver by Martin, Simon. Download PDF EPUB FB2

After 28 days exposure, triadimefon produced more toxic effects on the liver than observed for triadimenol. Besides this, triadimefon and triadimenol exposure exerted a greater effect on liver histology and thyroid hormone levels in male frogs than in the by: 1.

Xenopus laevis oocytes have been used in many studies as an expression system for the cloning of membrane proteins, in particular transporters. This involves the analysis of ligand transport in oocytes injected with RNA that is transcribed from successive subdivisions of cDNA libraries until a single positive clone is obtained.

The process by which the egg-yolk protein precursor vitellogenin is biosynthesized, assembled and secreted by Xenopus laevis (South African clawed toad) liver was studied. It was previously shown in other laboratories that vitellogenin contains the two egg-yolk proteins lipovitellin ( ) and phosvitin ( 35 ).Cited by: 8.

The ingested material travels down a series of tubes (esophagus, stomach, intestines), and accessory organs (liver, gall bladder, spleen) secrete compounds into the digestive tubes to aid in.

Effects of hormones on the ultrastructure of hepatocytes. Light microscopic examination of p-phenylendiamine stained semithin sections showed that the liver parenchyma of Xenopus laevis was composed of cords of several polyhedral cells.

The nuclei of the hepatocytes usually occupied the pole opposite from the bile canaliculus. The effects of capping and adding a poly(A) tail on the stability, movement and translation of these RNAs in Xenopus oocytes was examined.

Capping and polyadenylation increased stability of the transcripts, with at least 40% remaining intact 48 h after injection into by: early development of Xenopus, protein extracts were pre-pared by direct lysis in SDS sample buffer from 2-cell stage control embryos (n = 10), embryos at the 2-cell stage treated with Cx43 antisense RNA (n = 10) and embryos in-jected with antisense RNA and rescued with CT-Cx43 mRNA (n = 10).

Rat liver and heart were used as a positive control. I shall review the current knowledge about the hormonal control of gene expression in the following five systems: induction of egg white proteins in the chick oviduct, vitellogenin synthesis in Xenopus liver, casein synthesis in the rat mammary gland, the synthesis of α–amylase in barley aleurone layers, and ecdysone in insect development.

by: 2. Chapter Hormones 1. Chapter 45 Hormones: The Body’s Long- Distance Regulators • Animal hormones are chemical signals that are secreted into the circulatory system and communicate regulatory messages within the body • Hormones reach all parts of the body, but only target cells are equipped to respond.

Activin and inhibin are two closely related protein complexes that have almost directly opposite biological effects. Identified inactivin enhances FSH biosynthesis and secretion, and participates in the regulation of the menstrual other functions have been found to be exerted by activin, including roles in cell proliferation, differentiation, apoptosis, metabolism HGNC: Thyroid hormones are essential for brain developat through specific time windows influencing neurogenesis, neuronal migration, neuronal and glial cell differentiation, myelination, and synaptogenesis.

The actions of thyroid hormones are mostly due to interaction of the active hormone T3 with nuclear receptors and regulation of gene expression. T4 and T3 also perform non-genomic actions.

The Cited by: Abstract. The most important iodothyronine secreted by the thyroid gland is 3,5,3’,5’-tetraiodothyronine (thyroxine, T 4).Thyroxine has little, if any, biological activity, and is converted to the active hormone par excellence, i.e.

3,5,3’-triiodothyronine (T 3).In man about 80% of total plasma T 3 production is extrathyroidally converted to T 3 (see below), while 20% is secreted by the Cited by: The effect of exogenous oestrogen and follicle-stimulating hormone (FSH) on the concentration of serum lipids and protein has been investigated in the South African clawed toad, Xenopus laevis Daudin.

Abstract. Heterologous proteins can be expressed in Xenopus laevis oocytes by cytoplasmic microinjection of mRNA. To circumvent limitations inherent in this approach we investigate direct nuclear injection of strong viral expression vectors to drive transcription and subsequent translation of cDNAs encoding cytoplasmic, secreted, and plasma membrane by: precursor protein, vitellogenin, as well as the synthesis of smaller amounts of several other intracellular and secreted proteins ().

In Xenopus laevis estrogen administration results in almost complete commitment of the liver to vitel- logenin synthesis, which can account for as much as 70% of liver cell protein synthesis (4, 5). Effect of background adaptation on levels of newly synthesized proteins and RNA expression in the pituitary gland of Xenopus laevis.

(A) Animals adapted to black or white backgrounds for three weeks. Effects on metabolism may be due primarily to membrane acyl changes. There are other actions of thyroid hormones involving membrane receptors and influences on cellular interactions with the extracellular matrix. The effects of thyroid hormones are reviewed and appear to be combinations of these various modes of by: Direct Activation of Xenopus Iodotyrosine Deiodinase by Thyroid Hormone Receptor in the Remodeling Intestine during Amphibian Metamorphosis Article in Endocrinology (10) August Thyroid hormones are two hormones produced and released by the thyroid gland, namely triiodothyronine and thyroxine.

They are tyrosine-based hormones that are primarily responsible for regulation of metabolism. T3 and T4 are partially composed of iodine. A deficiency of iodine leads to decreased production of T3 and T4, enlarges the thyroid tissue and will cause the disease known as simple goitre.

The major form of thyroid hormone in the blood is thyroxine. The malectin protein gene was originally identified in Xenopus laevis in the search for proteins that are developmentally regulated in the pancreas.

However, it was soon found to be broadly expressed in embryonic and adult X. laevis, and moreover detected in all tissues examined (Schallus et al., ). Abstract. Xenopus is an excellent model for studying thyroid hormone signaling as it undergoes thyroid hormone–dependent metamorphosis.

Despite the fact that receptors and deiodinases have been described in Xenopus, membrane transporters for these hormones are yet to be cloned Xenopus monocarboxylate transporter 8 (mct8) and organic anion Cited by: 5.Thyroid Hormones and Derivatives: Endogenous Thyroid Hormones and Their Targets Chapter in Methods in molecular biology (Clifton, N.J.) .Abstract.

Heterologous proteins can be expressed in Xenopus laevis oocytes by cytoplasmic microinjection of mRNA. To circumvent limitations inherent in this approach we investigate direct nuclear injection of strong viral expression vectors to drive transcription and subsequent translation of cDNAs encoding cytoplasmic, secreted, and plasma membrane proteins.